of a new vaccine for skin cancer gets under way in the uk. it's designed to tackle the deadliest form of skin cancer, melanoma, and has raised hopes of a breakthrough. i just think it's a great thing. i think it's really exciting, really exciting. my geek radar is off the scale! a key figure at the post office during the horizon it scandal gives evidence at the public inquiry for a second day. humza yousaf weighs up his future as he faces a vote of no confidence after his power—sharing deal with the greens collapsed. and two of the most valuable items ever to be salvaged from the titanic, which go under the hammer this weekend. and coming up on bbc news, liverpool managerjurgen klopp says city and arsenal will see the title race as a two—horse race, but says he's not in the mood to wave a white flag.

good afternoon and welcome to the bbc news at one. a ground—breaking vaccine for melanoma skin cancer is being trialled in the uk. the jab, which is personalised, uses the same technology as that in some covid vaccines. early studies show that when used with another cancer drug — it almost halved the risk of recurrence or death after three years. melanoma is the most serious form of skin cancer and can spread to other areas of the body. the main cause of melanoma is ultraviolet light which comes from the sun and is used in sunbeds. around 17,500 people are diagnosed with melanoma each year in the uk. it's the uk's fifth most common cancer, but experts say 86% of these cases could be prevented by taking the right precautions. here's our health correspondentjim reed.

could a jab like this change the way cancer is treated? last month, steve young became the first person in the uk to be given this personalised vaccine, not to prevent the disease, but to try to stop a skin cancer returning. at least by being on a trial, i'm actively doing something that, you know, i'm having a fight, basically, i'm having a fight with whatever it was that gave me a melanoma. last summer, steve had this tumour removed from his scalp. those same cancer cells were flown to the united states and used to make the new experimental treatment. by priming, or preparing, his immune system, the hope is that steve's own body can better find and attack any cancer cells left over after his surgery. the trials being run at this

hospital in london and others are based on the same technology used in some covid jab called mrna, combined with a second treatment. early research suggests it significantly reduced the risk of this specific skin cancer called melanoma returning three years after surgery. researchers hope the same approach could work more widely. the real potential here, of course, is expanding this into other cancers because it's not a technology that just works in one cancer. if it works in melanoma, it could work across a number of different cancers, lung cancer, bowel cancer, kidney cancer etc. so there's a potential here for a really transformative change in how we treat patients with cancer. for patients like steve, a musician from hertfordshire, the hope is this personalised approach will one day sit alongside proven treatments like radiotherapy and chemotherapy.

weeks on from his treatment, he is thinking about his future. ifeel like i have this new lease of life and i'm actually really loving life at the moment, and ijust really hope that what's happening with the trial and the results they get are going to be good news and it's going to go on to do amazing things. the uk arm of this global trial is taking place at this hospital and seven other sites across the country. but this is still very early stage research, with full results not expected before the end of the decade. jim joins me now. so no full results for quite a while. how soon might patients benefit more widely? that while. how soon might patients benefit more widely?— while. how soon might patients benefit more widely? that is the key cuestion. benefit more widely? that is the key question- the _ benefit more widely? that is the key question. the vaccine _ benefit more widely? that is the key question. the vaccine we _ benefit more widely? that is the key question. the vaccine we are - benefit more widely? that is the key question. the vaccine we are talking | question. the vaccine we are talking about was developed by the us biotech company moderna. you might remember that name from the covid jabs. its big rival biontech, who developed the pfizerjab, is working on technology in the same area,

trying to use mrna jabs to treat other diseases, notjust cancer. i'm looking at a list of trials here — hiv, malaria, shingles, influenza, even cystic fibrosis. these trials are going on at the moment. we shouldn't get too carried away, though. there is a long way to go before anyone is receiving this regularly in the hospital or in pharmacy. it's one thing to develop these personalised vaccines for, say, cancerfor people in clinical trials, a few dozen people, quite another to scale this up so tens of thousands of patients could receive these on the nhs. so it's encouraging and exciting, but there is a long way to go, a lot of science to do yet.— is a long way to go, a lot of science to do yet. a key figure who handled many sub—postmasters�* complaints about the horizon it system has been giving evidence for a second day. angela van den bogerd was a senior figure at the post office for a number of years. our correspondent, zoe conway, joins us from the inquiry in central london.

the inquiry this morning has really been dominated by the story of martin griffiths, a sub—postmaster who took his own life in 2013. what they have been looking at is how the senior management at the post office behaved in the aftermath of his death. martin griffiths, a sub—postmaster in cheshire, for 18 years. the post office said he was responsible for tens of thousands of pounds of missing money. his contract, terminated, left a broken man. i appreciate you wouldn't have received this letter at the time. martin griffiths wrote to the post office in 2013, begging for help. "the financial strain on myself and my family is devastating and continues on a daily basis". but his family says — continues on a daily basis". but his family says the _ continues on a daily basis". but his family says the help _ continues on a daily basis". but his family says the help didn't - continues on a daily basis". but his family says the help didn't come. l continues on a daily basis". but his i family says the help didn't come. he took his own life. fin family says the help didn't come. he took his own life.— took his own life. on the 11th of october 2013, _ took his own life. on the 11th of october 2013, his _ took his own life. on the 11th of october 2013, his life _ took his own life. on the 11th of october 2013, his life support l october 2013, his life support machine was switched off and he passed away that day.—

machine was switched off and he passed away that day. while martin griffiths was _ passed away that day. while martin griffiths was in _ passed away that day. while martin griffiths was in hospital, _ passed away that day. while martin griffiths was in hospital, at - passed away that day. while martin griffiths was in hospital, at the - griffiths was in hospital, at the top of the post office, the media strategy was being prepared. please can we line up _ strategy was being prepared. please can we line up a _ strategy was being prepared. please can we line up a specialist _ strategy was being prepared. please can we line up a specialist media - can we line up a specialist media lawyer in case we need urgent advice this evening? so the immediate reaction, you agree, was not" is martin griffiths all right, what about his health?", was it? hot martin griffiths all right, what about his health?", was it? not at this oint about his health?", was it? not at this point in _ about his health?", was it? not at this point in this _ about his health?", was it? not at this point in this e-mail_ about his health?", was it? not at this point in this e-mail chain, - about his health?", was it? not at this point in this e-mail chain, no. this point in this e—mail chain, no. the immediate reaction was not "what can we, the post office, due to help this man's family? ”. can we, the post office, due to help this man's family?— this man's family? ", was it? not at this man's family? ", was it? not at this point- — this man's family? ", was it? not at this point. what _ this man's family? ", was it? not at this point. what about _ this man's family? ", was it? not at this point. what about his _ this man's family? ", was it? not at this point. what about his wife - this man's family? ", was it? not at this point. what about his wife and l this point. what about his wife and children? what _ this point. what about his wife and children? what about _ this point. what about his wife and children? what about his _ this point. what about his wife and children? what about his elderly i children? what about his elderly parents? what about his sister? should we get somebody down to the hospital? that didn't happen, did it? not getting somebody down to the hospital. the first thing was, let's get a media lawyer.— hospital. the first thing was, let's get a media lawyer. when i saw this,

i didn't get a media lawyer. when i saw this, i didn't know — get a media lawyer. when i saw this, i didn't know martin. _ get a media lawyer. when i saw this, i didn't know martin. this _ get a media lawyer. when i saw this, i didn't know martin. this was - get a media lawyer. when i saw this, i didn't know martin. this was my - i didn't know martin. this was my first involvement in it and i was genuinely— first involvement in it and i was genuinely concerned for the family. there _ genuinely concerned for the family. there didn't seem to be any end to it. a, , , ,�* ., there didn't seem to be any end to it. martin griffiths' widow gina soke to it. martin griffiths' widow gina spoke to bbc _ it. martin griffiths' widow gina spoke to bbc panorama - it. martin griffiths' widow gina spoke to bbc panorama two . it. martin griffiths' widow gina - spoke to bbc panorama two years ago. the worst thing for me was seeing my chiidren— the worst thing for me was seeing my children having — the worst thing for me was seeing my children having to _ the worst thing for me was seeing my children having to see _ the worst thing for me was seeing my children having to see their— the worst thing for me was seeing my children having to see their dad - children having to see their dad die. children having to see their dad die and — children having to see their dad die and it _ children having to see their dad die. and it was _ children having to see their dad die. and it was purely- children having to see their dad die. and it was purely down - children having to see their dad die. and it was purely down toi children having to see their dad i die. and it was purely down to the post office — die. and it was purely down to the post office. the _ die. and it was purely down to the post office-— post office. the post office gave gina griffiths — post office. the post office gave gina griffiths £140,000 - post office. the post office gave gina griffiths £140,000 payoff, | post office. the post office gave i gina griffiths £140,000 payoff, but gina griffiths £1a0,000 payoff, but it was confirmed today that she had to sign a confidentiality agreement. zoe conway, bbc news. if you are suffering distress or despair and need support, a list of organisations that can help is available at bbc.co.uk/actionline, or you can call forfree on 0800 066 066.

a 13—year—old girl has been remanded to youth detention accommodation after being charged with three counts of attempted murder, after two teachers and a pupil were stabbed at a school in south—west wales. police said the teenager was arrested at the school in ammanford in carmarthenshire. the teachers and pupil were taken to hospital with non—life—threatening stab wounds, and have since been discharged. two men who were arrested after five people died trying to cross the channel in a small boat earlier this week have been charged with immigration offences. yien both from south sudan, and tajdeen adbulazinuma from sudan, are due to appear before folkestone magistrates court today. an 18—year—old man from sudan has been bailed pending further enquiries. a baby whom we filmed earlier in the week being rescued from her dying mother's womb after an israeli air strike in southern gaza has died. baby sabreen al—sakani was delivered by caesarean section in a hospital in rafah shortly after midnight on sunday. our correspondent, fergal keane,

sent this update from jerusalem. well, we got the news late last night in a phone call from an uncle of baby sabreen, who said that she had died yesterday morning and the family had buried her by 1pm. now, this story begins last saturday night with an israeli air strike on the family home. the israel defence forces say they were going after hamas operatives and hamas infrastructure. the missile hit the family home. it killed sabreen's father. it killed her three—year—old sister, malak, and then her mother, badly injured, was rushed to a local hospital, and that's where we saw these dramatic scenes of baby sabreen being born. she was born through a caesarean section on her mother, and then doctors tried to resuscitate her, tapping her chest to stimulate breathing,

putting an air pump into her mouth and then placing her in an incubator, and it looked at that time as though there was a fragment of hope, that out of this terrible tragedy, some life would survive. of course, at that time, we should point out, doctors were saying her condition was critical. and indeed, one of the doctors, dr salama, who looks after the emergency care in the neonatal unit at emirati hospital, he did say, "if she survives". well, we now know that that didn't happen. baby sabreen joins the 16 other children who were killed that weekend in air strikes by israel. we're told also by family members that they would have been more than willing and were indeed happy at the prospect of adopting her. mirvat al—sakani, the maternal grandmother of baby sabreen,

when ourjournalist colleague visited her in the refugee tent where she's living, she was scrolling through photographs of her daughter, speaking directly to her daughter and promising that she would take care of the child, along with the paternal grandmother, and also saying in that interview that she did with us, "well, you will see baby sabreen in heaven". this is how the story ends, i'm sad to say — baby sabreen dying, doctors doing their very best to try and save her, but not being successful. our correspondent fergal keane reporting there. scotland's first minister humza yousaf is considering his next moves after ending the power—sharing agreement with the scottish greens. he now faces a vote of no confidence. the greens said they would vote against mr yousaf, meaning his survival may depend on the vote of his former colleague ash regan, who defected from the snp to the alba party last year.

our scotland correspondent, lorna gordon, is in dundee where mr yousaf has been speaking. how do things done for him? in the last few minutes, _ how do things done for him? in the last few minutes, humza _ how do things done for him? in the last few minutes, humza yousaf i how do things done for him? in the | last few minutes, humza yousaf has how do things done for him? in the i last few minutes, humza yousaf has a right this housing development in dundee. he ignored brutal question from the waiting media about he would continue as first minister, whether he was a lame duck first minister, but we are told he will do interviews later. he is trying to reset his government by making this announcement about affordable housing. but to be honest, all focus is on his future. we are told he will not be announcing his resignation today, despite speculation overnight about his future. but as he was travelling here came the news that he is facing notjust here came the news that he is facing not just one, here came the news that he is facing notjust one, but two votes of no confidence. yesterday, the conservatives tabled that motion of no confidence in him and this

morning, labourtabled no confidence in him and this morning, labour tabled a motion of no confidence in the snp government. they have said it is untenable for the snp to assume it can impose another unelected first minister in scotland and it should be for the people of scotland to decide who is first minister, notjust the snp. so it looks likely that humza yousaf will face two votes of confidence at some point next week, perhaps as early as wednesday. in the meantime, he has to get either the greens or ash regan, who lost out to him in the snp leadership contest, on board in order to survive.— in order to survive. lorna gordon reporting- _ two british men have been charged with helping russia after a suspected attack on a ukrainian—linked business. they are the first people to be charged under the new national security act 2023, which was designed to strengthen the uk's defences against hostile activity by other states. our home affairs correspondent daniel sandford is here. what more can you tell us? for a

week, what more can you tell us? for a week. we — what more can you tell us? for a week, we haven't _ what more can you tell us? for a week, we haven't been _ what more can you tell us? for a week, we haven't been able - what more can you tell us? for a week, we haven't been able to i what more can you tell us? for a | week, we haven't been able to tell you anything, because reporting restrictions meant we could not reveal the key details of the case. those restrictions were imposed by a court on saturday. now the first tranche of court appearances is over, those restrictions were lifted this afternoon. it all relates to a fire at two industrial units and latent in east london which took place in march, march the 20. it is a business owned by a ukrainian businessman and his latvian wife. what has risen out of that is that this 20—year—old man from leicestershire has been charged with aiding a foreign intelligence service. he has also been charged with arson. the 22—year—old british man, jake reeves, has been charged with receiving intelligence from a foreign service. this is new legislation last year which was

aiming to modernise the laws about foreign interference in espionage. four other people have also been charged link to this case. three other people have been charged link to the fire and one person charged with not telling police about a terrorist act. the time is 1.16. our top story this afternoon: a pioneering trial of a new vaccine for skin cancer gets under way in the uk and raises hopes of a breakthrough. and still to come: the major study that offers a "ray of light" for those working to protect threatened animals and plants. coming up on bbc news, the end of an era for brazil as their all—time record goalscorer marta says she'll retire from international football at the end of the year. ahead of the 80th anniversary of the d—day landings, schoolchildren in london have spent the morning taking part

in a history lesson like no other. they've been given the chance to speak to veterans about what it was really like on the beaches of normandy. our correspondentjohn maguire is at the unionjack club in central london and can tell us more. yes, rita. look, whatan yes, rita. look, what an amazing line—up of gentlemen. 98, 99, even donald in the middle there, 103 years old. all veterans of the normandy operation, the allied invasion of northern europe. they are here to look forward to the 80th commemoration of d—day, the 6th of june, 19114, originally. they will be looking forward to that of the summer, but also to launch this education pack sponsored by the british council to teach the current generation about what these men went through 80 years ago. it is all about that link between the greatest generation and our youngest

generation. when the second world war broke out, these veterans of the normandy landings were the same age as some of the schoolchildren they're meeting today. we and my colleagues, we went through it. we know the little stories. and it's important that they know for the future of the world. the world looks a desperate place at the moment. and, please god, somebody will see sense, we don't need to go through all that again. what do all the medals mean to you? their first—hand account is a living history lesson like no other. it's been amazing today, because in history, - we've been learning about world war ii and d—day and all the stuff- that has happened. and then we've come here today. and we've heard it from the people who've actually lived in it and been through it, - and it'sjust been spectacular. when you think of learning about history and d—day, you always watch movies, you read books, you think of all these things, but then you never really realise what it's like until you hear these people actually talking about it. the allied invasion of northern france succeeded in wresting europe from nazi occupation.

the british normandy memorial above what was codenamed gold beach carries the names of those under british command who died securing the coastline and fighting towards the liberation of paris. now the site is about to embark on a new phase with the opening this summer of an education centre, as nicholas witchell, a trustee, explained to me last week. phase one was the memorial. phase two has always been the education centre. education is so important. it was always a priority for the veterans. we've got to get the message through to younger generations to remember and to understand. the ages of the fallen immortalised in stone here tell the story of how so many died so young. there were teenagers serving on d—day, so any veterans are today well into their 90s, if not older. those able to do so will return to normandy for the 80th anniversary this summer to reflect, to remember and to carry vital messages.

we're launching the education pack. material has been put together so that we can tell future generations just what d—day was, what the normandy campaign was, and how this was a british—led operation which brought peace and freedom back to europe. these men who gave so much 80 years ago believe in sharing now, helping people to understand the sacrifices their comrades and friends made, and hoping future generations will never be asked to do the same again. john maguire, bbc news, london. a group of five women have accused a judge of bullying and sexist behaviour towards them. one woman told bbc news she was shouted at on at least 16 occasions. the women all brought separate employment tribunal cases before judge philip lancaster. a spokesperson for the judiciary said they couldn't comment on matters of conduct. from leeds, michael buchanan reports.

three women, three separate court cases, onejudge. would you like to apologise to any of them in any way? dr hinaa toheed brought a maternity discrimination case against herformer business partner in 2022. when the barrister on the other side started to cross—examine me, the judge completely took over the cross—examination, started aggressively cross—examining me. and if i didn't agree with anything that he said, he would shout at me. the gp's barrister counted at least 16 occasions on which that had happened. i was told by my barrister that what was going on in court was deeply disturbing, and they were very, very concerned that the judge was behaving in an extremely, um, intimidating and aggressive manner with me. hostile is the word that they used. and this is thatjudge. philip lancaster has presented over employment tribunals since 2007,

and hinaa toheed is far from the only woman to complain about his conduct. in 2021, andra appeared before a judge, representing her partner in a race discrimination case he had brought against his company. i've been shouted at constantly. i've been interrupted. i felt abused. as his legal representative, andra was allowed to question witnesses from her partner's former company, but as an appeal court would laterfind, she was repeatedly prevented doing so. he literally interrupted me whenever i was asking any questions, saying it is either irrelevant or i shouldn't ask this today, i should ask another witness, not this witness. then when we got to the other witness, he would say, "why didn't you ask the other witness yesterday?" all the cases were heard in a courtroom in this building in central leeds, but proving misconduct is extremely difficult, as there were no

objective documents made. despite each case being an official court hearing, employment tribunals at that time were not recorded. that meant thatjudge lancaster's notes on what had happened became the official court record. alison mcdermott brought a case against her employer in 2021 after being sacked. she sastudge lancaster shouted at her too, and made snide remarks about her earnings. i think it matters hugely that i was a woman. i think for some reason, he had a real problem with the fact that i was a well—paid professional woman. when herjudgement received some publicity, the hr consultant was contacted by the other women and learned of their complaints about the judge. as usual, it's left to the victims to find one another, come together and say, "we're not accepting this". excuse me, mr lancaster? yes. bbc news. we approached judge lancaster with the group's concerns. several women have accused

you of bias, bullying and misogyny. what would you say to them? would you like to apologise to any of them in any way? in a statement, the court and tribunaljudiciary said, "we cannot provide comment in response to any conduct allegations". this is someone who has been allowed to behave like this, unchecked. the women, who all lost their cases, now provide support to each other, but say their previously fundamental belief in the fairness of british justice has been shattered. michael buchanan, bbc news, leeds. a lawyer who lost herjob during the pandemic and decided to focus on running instead hasjust been told she is going to the olympics to represent team gb in the marathon. 31—year—old rose harvey only started

running 10 years ago when she moved to london and joined a club to get fit and meet people. but it turned out she's quite good. she ran the london marathon a few years later in three hours. but it was during lockdown that her times really improved. she went from good club runner to olympic qualifier when she finished the chicago marathon last year in 2:23. there's strong evidence that global efforts at conservation are working, according to a study published in the journal science. the research took ten years, and looked at more than 600 conservation trials from around the world. the authors say some extinctions have been prevented and that the decline in biodiversity is being slowed. here's our climate and science reporter, esme stallard. biodiversity is declining at a faster rate than at any other time in human history, driven by climate change and habitat loss. but researchers from the environmental charity rewild and the universities of oxford and kent found that most

cases, conservation measures were more effective at slowing it than doing nothing at all. the success stories they found included deforestation rates falling 74% in the congo basin following the introduction of management plans. turtle breeding rates increasing because of predator management in florida's barrier islands. ii because of predator management in florida's barrier islands.— florida's barrier islands. if they are working. — florida's barrier islands. if they are working, they _ florida's barrier islands. if they are working, they are - florida's barrier islands. if they are working, they are clearly i florida's barrier islands. if they l are working, they are clearly not being funded at scale, at a sufficient scale to actually start to reverse global declines in biodiversity, and i think that is the key thing, to say that first of all, conservation is working, second of all, we are just not doing enough of all, we are just not doing enough of it now. it's estimated that funding levels need to almost double to meet this global biodiversity framework goal, signed by 200 countries and 2022, of halting the decline in nature by the end of the decade. esme stallard, bbc news. two of the most valuable items ever recovered from the titanic are coming up for auction tomorrow. they're a violin case belonging

to the man who led the orchestra on deck as the ship sank in 1912 and a gold watch worn by one of the richest men in the world. duncan kennedy reports. it was supposed to be the defining standard of nautical opulence. the titanic — totemic of a new era of human achievement. but on the night of april 1ath, 1912, the ship hit an iceberg in the north atlantic and sank. more than 1,500 people died. now, two of the most valuable personal items ever recovered from the disaster are coming to auction — a bag and a watch belonging to two people whose stories have become fables from that fateful night. the james cameron movie titanic... hey, astor! ..depicts both men. well, hello, molly. jothacob astor,

the wealthiest man on board and one of the richest in the world, and wallace hartley, the violin player who bravely led the orchestra to calm passengers' nerves as the vessel floundered, each man central to the film's narrative of bravery and loss. in real life, both hartley and astor died that night, their bodies and their possessions recovered in the aftermath. you've got the bag and the watch? correct. andrew aldridge, a world expert on the titanic, says hartley possibly tried to use his violin case and its straps as a flotation device, but it came to nothing, whilst jj astor's14—carat gold pocket watch was discovered amongst his personal effects in the days after the tragedy. why is there this continuing public obsession and interest in all things to do with the titanic? i honestly think it's to do with the people. she transcends so many different levels. we're fascinated in her because of who was on board.

you could argue that titanic is the most famous ship that's ever sailed, apart from the ark. so what might they fetch at the auction? well, the estimated price on the bag is £120,000. and for the watch, it's £150,000, and just shows the continued interest there is in all things titanic. wallace hartley's violin itself was sold separately in 2013 for £1 million. it's now on display at the titanic museum in belfast. tomorrow's auction, streamed live, will attract bidders from around the world, ready to spend as they save these unique items from a ship enshrined in maritime folklore. duncan kennedy, bbc news. time for a look at the weather. here's chris fawkes.

is it going to get any warmer? it will eventually, next week. but before we get there, a few cold days to come. and speaking of cold weather, do you know, this morning, weather, do you know, this morning, we had not only a widespread frost, but temperatures managed to get all the way down to —6 celsius in cumbria. so a really cold start to the day. but this month has been quite dull. the sunshine many of us have enjoyed so far this morning, i'm sure, will have been quite welcomed. however, we start to see shower clouds develop really widely now with some thicker, frontal cloud down towards the south—west of england bringing a threat of rain. shower clouds are developing. we have seen plenty of those in northern ireland already. through the afternoon, showers continue here, continuing to affect northern and eastern scotland, continuing to come across the pennines and to the north west of england. more general reign in south—west england,

particularly parts of devon, and a few spots of rain